Gene Regulation in Neurons
Nearly 80% of the genome gets transcribed to produce a wide diversity of RNA transcripts, but only a minor fraction (approximately 2%) gets translated into proteins. Non-coding RNA form the largest class of unknown regulatory RNAs in our cells and offer a solution to the long-standing G-value paradox in biology.
Some questions that fascinate us
Polyglutamine toxicity
Abnormally long polyglutamine (polyQ) stretches in proteins are toxic to neuronal cells. How do they cause neuronal cell death? Are these steps preventable or reversible? Which non-coding RNAs are involved in polyQ mediated neuronal cell death? Why are neurons more vulnerable than other cells? Why are some regions of the brain more affected in certain polyQ diseases?
Inherited non-coding RNAs
About one in seven non-coding RNAs are inherited via the gametes. What are their distinct and overlapping roles in the development of the nervous system? Are their consequences to changes in the pool of inherited RNAs?
The vermicomposting earthworm Eisenia fetida regenerates its body after amputation. What unique factors and gene regulatory networks allow it to regenerate its nerves after injury? Can these factors be harnessed to promote regeneration in mammals?
ncRNA biomarkers
Earthworm regeneration
Our research projects require us to measure non-coding RNAs in biological samples. We work with clinicians and collaborators to help other groups identify miRNA biomarkers in human samples.
What we look for in a labmate:
We look for people who are more interested in the scientific question than in securing their own career. If you love coming to the lab every day, the rest will follow.
Attendance is not monitored on a day-to-day basis. But the nature of our work is laborious and most of us work well beyond the office hours and for a few hours on most weekends. The lab members take on additional responsibilities going beyond their research, chipping into administrative work, reviewing, grant writing and outreach.
Creativity
Passion
Communication
Compassion
and some appreciation for the unique opportunities and problems that come with working in India.